20 April, 2007

Exposure to asbestos

Exposure to asbestos by Joseph Amainte

Asbestos is composed of fibers that can cause life threatening illness, such as mesothelioma (a cancer), among others. Many companies are being proactive and having asbestos removed before it can harm someone. It can live safely behind walls or ceilings, but as soon as any fibers escape, people may inhale them and become ill. It only takes a tiny amount ingested into the lungs. Unfortunately, the symptoms may not be visible for as long as 40 years, so it’s difficult to prevent getting sick from an unknown source.

Typically, a person becomes exposed to asbestos from work or even home but a third risk is for people that live near places such as shipyards, steel mills, power plants, refineries, and so on where asbestos is used. What happens is that the fibers become disrupted, contaminating nearby residential areas. In addition to the industries mentioned, other common areas include maritime, construction, automotive repair (specifically brakes and clutches), roofing, and railroads.

Just as asbestos can be a serious problem for some types of businesses, it can also exist in many homes and schools. Prior to the 1970s, some materials used for building structures contained asbestos. In fact, an estimated 30 million tons of asbestos fiber was used just in the U.S. during this time, with some winding up in homes and schools.

How can you make sure your home is free of asbestos? First,remember that your home, even if it was built before 1970, does not necessarily contain asbestos. The majority of individuals that have developed health problems related to asbestos worked in industries where asbestos was prevalent, but were not exposed in their home. In addition, bear in mind that the majority of people exposed to small amounts of asbestos do not become ill.

However, if for any reason, you r suspect that your home may have asbestos products, contact the Environmental Protection Agency (EPA) to request a listing of licensed or certified techniques who can check the home for asbestos and if found, remove it. The EPA may also recommend that you contact a separate firm to have them conduct an assessment to confirm there is no asbestos present from the other finding.

If you plan on building a home always check the materials used carefully to see if they are labeled free of asbestos. Until you verify that each product is safe, contact the product manufacturer to find out exactly what is contained in each product.

When you purchase a home from a private seller, the seller is required by law to disclose any known hazards to you, including asbestos. Apartment buildings built prior to 1970 may have materials that include asbestos in their construction. Remember that asbestos only becomes truly dangerous when the product breaks down or opens, until then it is not a health risk.

In 1995 the Occupational Safety and Health Administration (OSHA) set guidelines for asbestos discovery and follow-up in work environments. Any time it’s found, employees must be notified. The same applies to rental units. If your potential landlord informs you of existing asbestos, it will be your choice to live there or not.

Joseph Amiante provides a range of resources at his web site: Asbestos Pain, where you will find information that will help you on many asbestos related issues. Why not take a look: http://www.asbestospain.com

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Mesothelioma a cancer caused by asbestos

Mesothelioma a cancer caused by asbestos by Paul Wilson

The internal organs of the human body are encased in a protective sac called the mesothelium. Examples of mesothelilial membranes are the peritoneum (abdominal organs), pleura (lungs), and pericardium (heart).

Under specific conditions, the cells of the protective membrane divide uncontrolled and become cancerous. This disease is termed as Mesothelioma, a rare form of cancer which is caused by prolonged exposure to asbestos dust.

The disease is found to occur among those who work in shipyards, asbestos mines and factories, industries that produce asbestos based products, and the heating and construction businesses. Approximately 3,000 cases occur each year in the US, and most patients are between 50-70 years old. Statistics show that males are commonly affected and among them whites more than African Americans.

First studied in the late 1700s in depth studies were only done in the 1960s. Tumors of the Mesothelioma can be benign or malignant. The malignant Mesothelioma are categorized into three types:

• Epithelioid, accounting for 50-70% of mesotheliomas.
• Sarcomatoid, accounting for 7-20%.
• Mixed or bi-phasic, accounting for 20-35%.

When asbestos fibers are breathed into the lungs they travel through large air passages to reach the smaller passages and from them the pleura. In the pleura they damage: the mesothelial cells leading to cancer; lung tissue causing lung cancer; and the development of scar tissue within the lungs known as asbestosis. When asbestos fibers are swallowed they reach the abdominal cavity and cause peritoneal mesothelioma.

Research reveals that the disease only manifests 20-50 years after being exposed to asbestos dust. The symptoms are not specific to the disease but a patient may develop:

• Breathlessness.
• Chest pain accompanied by tightness believed to be caused by accumulation of fluid in the pleura.
• Low back pain.
• Swelling of face and arms.
• Sensory loss.
• Muscle weakness.
• Nausea.
• Vomiting.
• Weight loss that is unexplained.
• Persistent dry cough.
• Sore throat.
• Anemia.
• Fever.
• Constipation.
• Problems with blood clotting.

Since the above are common to minor ailments, patients often ignore the symptoms. It is advisable to consult a doctor if any of the above symptoms persist or if you feel you have been knowingly or unknowingly exposed to asbestos.

A doctor will:

• Take down a detailed medical history and try and determine the symptoms and risk factors.
• Do a thorough physical examination and check for signs of:

o Pleural effusion, fluid accumulated in the chest cavity.
o Fluid in the abdominal cavity.
o Pericardial effusion, fluid in the lining of the heart.

• Take a chest x-ray and check for thickening of the pleura, calcifications, and lowered lung fissures.
• Ask for a CT scan to determine clearly the location, size, and extent of the problem if any is suspected.
• Recommend tests of tissue samples and pleural fluids.

Other risk factors are cigarette or cigar smoking, exposure to radiation, exposure to zeolite a compound that is similar to asbestos, exposure to or infections caused by SV40, a Simian virus.

Those who work in a risky environment should wear protective clothing, have the surroundings tested regularly for suspended asbestos particles, and ensure that they have regular medical tests and report to the doctor any ailments that persist.

Being aware of the disease and its problems helps.

Paul Wilson is a freelance writer for http://www.1888Discuss.com/health/ , the premier REVENUE SHARING discussion forum for Health Forum including topics on health care, Children's Health Issues, addiction, Cancer, fitness equipment, Burns & Injuries and more. His article profile can be found at the premier Health Article Submission Directory http://www.1888Articles.com/health-articles-8.html

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10 Options in Treating Mesothelioma

10 Options in Treating Mesothelioma by Paul Wilson

As with any cancer, treatment for Mesothelioma depends on the location of the cancer, the progression of the disease, the age as well as state of health of the patient.

It is the oncologist who specializes in the disease who will decide on the line of treatment. The disease is difficult to treat and in most cases the prognosis is poor. Treatment options include:

1. If the diagnosis is done in the early stages surgery may be recommended to remove all cancerous tissues. This means thoracoscopy, VATS or video assisted thoracic surgery, mediastinoscopy (used for staging), or laproscopy. Often, doctors will advise palliative procedures like chest tube drainage and pleurodesis, thoracoscopy and pleurodesis, pleuroperitonial shunt, or pleurectomy, which treat the symptoms of mesothelioma rather than the disease.

2. Radiation is prescribed aggressively for mesothelioma patients and is often given in combination with surgery or in order to control symptoms, palliatively. Research on using radiation therapy using implants or UV light therapy is in progress as traditional radiation therapy damages surrounding healthy tissue.

3. Chemotherapy is an option and around 12-20% of patients respond to the drugs. Anti-cancer drugs destroy cancer cells and prevent their spread. In mesothelioma, chemotherapy is not considered to be curative. The aim is to prevent spread of the disease; shrink the tumor prior to surgery, known as neoadjuvant therapy; to annihilate any remains of the tumor in the body post surgery; and to relieve pain and other discomfort, palliative chemotherapy. Experts recommend prescribing premetrexed along with cisplastin. These drugs have shown positive results and this is now standard care for Mesothelioma not treatable by surgery.

4. Biological therapy using interleukin 2.

5. Immunotherapy where the body’s own immune system is stimulated to fight the disease. Biological response modifiers, BRMs, are used in treatment. These enhance the functions of the immune system; regulate metabolic reactions that promote growth of cancers; alter cancer cell division; block or reverse processes that lead to formation of cancers; and prevent spread of cancer.

6. Gene therapy, where attempts are made to correct the gene sequence that causes the cancer. This is of two kinds, replacement gene therapy and knockout gene therapy.

7. Administration of lovastatin, a cholesterol lowering drug.

8. Photodynamic treatment where a photosensitive medication is activated using a laser. This is done during the surgical removal of cancerous tissues.

9. Draining of fluid in the chest or abdominal cavity followed by introduction of medications into the cavity to prevent fluid accumulation is done for patients who have uncontrolled fluid accumulation and intense discomfort stemming from it.

10. Combination therapy or Trimodal therapy which means surgery accompanied by radiation and chemotherapy.

Often, complementary medicines are also used. Termed to be holistic this kind of treatment focuses on a patient’s physical, mental, emotional, and spiritual well being.

In the case of Mesothelioma which is untreatable one can opt for clinical trials of new treatments that are in progress in several research laboratories and centers. The best advice on the line of treatment would be that recommended by the oncologist or physician.

Paul Wilson is a freelance writer for http://www.1888Discuss.com/health/ , the premier REVENUE SHARING discussion forum for Health Forum including topics on health care, Children's Health Issues, addiction, Cancer, fitness equipment, Burns & Injuries and more. His article profile can be found at the premier Health Article Submission Directory http://www.1888Articles.com/health-articles-8.html

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Mesothelioma Screening

Mesothelioma Screening by Rick Ferring

If you or a family member has been knowingly exposed to asbestos either through work, house renovations or some other way, it’s important to go and have a physical checkup done. Make sure you tell the physician about the exposure and how long ago it happened. If your exposure was anywhere in the last ten to fifteen years it is quite possible that nothing will show up in the physical exam. This is because asbestos related diseases tend to incubate or lie dormant for many years. Early detection is very important for hope of proper treatment. Any asbestos workers from the shipbuilding, asbestos mining, and manufacturing industries are at particular risk.

Particularly in the early stages, asbestos-related diseases can easily be mistaken for other conditions. This makes it all the more important to screen properly.

Screening involves several steps. The first step a doctor will do after collecting all the history and basic medical information will be to use a thorascope. This procedure is called a Thoracoscopy, which involves a tiny incision into the chest. A sample of lung tissue can be removed to determine whether it is cancerous. This procedure is usually done in a hospital setting with a local anesthetic. It causes little to no pain. He may also order a regular x-ray to see if anything abnormal shows up.

The second step involves a device called a peritoneoscope. This device looks inside the abdomen and can collect tissue samples at the same time. The physician will also be looking for excess fluid. At this time, he has the capacity to drain off some of the excess fluid to relieve any pain.

The third step to mesothelioma screening is to conduct more advanced steps in case the previous ones were inconclusive. These advanced tests could include a Computerized Axial Tomography (CAT) scan. This scan gives a three dimensional x-ray of the tissue in question. This helps to see problematic areas before they get any worse.

A fourth step would be to order a Magnetic Resonance Imaging scan. This MRI uses high-energy magnetic fields as it takes cross-sectional pictures of the internal organs and skeleton. By seeing the internal structure, it is easier to distinguish healthy from diseased tissues.

Both of the above scans are tools that help physicians to recognize problems long before a patient begins to show any symptoms.

Even with the techniques available to day, mesothelioma often goes undetected. It is important to have regular screenings in anyone who has had prolonged exposure to asbestos. New research is ongoing. Eventually some viable treatment and even a cure will happen. If in the unfortunate circumstance, you are diagnosed with mesothelioma or another asbestos-related disease, you want to be in the best position to take advantage of the new treatments and that means early detection for best results.

Rick has been writing about health related topics for over 12 years. He specializes in mesothelioma and asbestos related ailments.

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Mesothelioma Cancer of the lung lining

Mesothelioma - Cancer of the lung lining by Garry.

Mesothelioma is a very rare form of lung cancer that arises in the mesothelium. The mesothelium is made up of parietal and visceral membranes, thin layers of tissue, which surround organs and body cavities, such as the lungs or abdomen. The visceral membrane immediately surrounds the organ, and the parietal membrane is a sac covering. The visceral and parietal membranes that make up the mesothelium. The mesothelium is referred to by different names, depending on what part of the body it is found in.

Dealing with mesothelioma

Dealing with mesothelioma is a very difficult process. It will require a lot of physical and emotional endurances. The best way to understand mesothelioma is to learn everything that you can learn about the disease. This should include the causes, symptoms, diagnosis, treatment and prognosis of mesothelioma- cancer of the lung lining.

Symptoms

Since mesothelioma-cancer of the lung lining takes a long time to develop inside a human body. It is often difficult to identify the symptoms. In the early stages there may not even be any symptoms at all. When they do appear the most common early symptoms are shortness of breath and chest pains.

Presentations and expectations

There are two major types of asbestos: chrysotile and amphibole. It is thought that exposure to the exposure to the amphibole form is more likely to cause mesothelioma-cancer of the lung lining. However, chrysotile has been used more frequently hence many mesothelioma are caused by chrysotile.

Removal is taking place in schools and other public buildings throughout the U.S. . The hope is that these measures will greatly reduce the occurrence of this cancer.

Long-term effects of the disease

A mesothelioma-cancer of the lung lining is a highly aggressive tumor that is generally deadly. Current treatment of malignant mesothelioma-cancer of the lung lining is designed to make the person with cancer comfortable.

Screening

There is no universally agreed protocol for screening people who have been exposed to asbestos. However some research indicates that the serum osteopontin level might be useful in screening asbestos- exposed people for mesothelioma. The level of soluble mesothelin- related protein is elevated in the serum of about 75% of patients at diagnosis and it has been suggested that it may be useful for screening.

Treatment

Once mesothelioma-cancer of lung lining has been diagnosed a treatment procedure can be recommended and begun. The correct treatment will depend on a number of factors. They include the location of the tumor, the stage of the disease and how far the cancer has spread in the patient. The recommendation will also depend on the age and overall health of the patient.

It is certainly not easy to deal with all of the medical, physical, emotional and financial issues that may be raised when dealing with a serious disease like mesothelioma-cancer of lung lining, but it always better to be prepared. We can just have a hope that in future as the medical science advances this incurable disease can also be cured and lives of many people can be saved.

About the Author
The Article is written by themesothelioma.org - Mesothelioma Treatment and taken from resources-free.com

13 April, 2007

Are new treatments for mesothelioma being studied?

Yes. Because mesothelioma is very hard to control, the National Cancer Institute (NCI) is sponsoring clinical trials (research studies with people) that are designed to find new treatments and better ways to use current treatments. Before any new treatment can be recommended for general use, doctors conduct clinical trials to find out whether the treatment is safe for patients and effective against the disease. Participation in clinical trials is an important treatment option for many patients with mesothelioma.

People interested in taking part in a clinical trial should talk with their doctor. Information about clinical trials is available from the Cancer Information Service (CIS) (see below) at 1–800–4–CANCER. Information specialists at the CIS use PDQ®, NCI’s cancer information database, to identify and provide detailed information about specific ongoing clinical trials. Patients also have the option of searching for clinical trials on their own. The clinical trials page on the NCI’s Cancer.gov Web site, located at http://www.cancer.gov/clinical_trials on the Internet, provides general information about clinical trials and links to PDQ.

People considering clinical trials may be interested in the NCI booklet Taking Part in Clinical Trials: What Cancer Patients Need To Know. This booklet describes how research studies are carried out and explains their possible benefits and risks. The booklet is available by calling the CIS, or from the NCI Publications Locator Web site at http://www.cancer.gov/publications on the Internet.

How is mesothelioma treated?

Treatment for mesothelioma depends on the location of the cancer, the stage of the disease, and the patient’s age and general health. Standard treatment options include surgery, radiation therapy, and chemotherapy. Sometimes, these treatments are combined.

* Surgery is a common treatment for mesothelioma. The doctor may remove part of the lining of the chest or abdomen and some of the tissue around it. For cancer of the pleura (pleural mesothelioma), a lung may be removed in an operation called a pneumonectomy. Sometimes part of the diaphragm, the muscle below the lungs that helps with breathing, is also removed.

* Radiation therapy, also called radiotherapy, involves the use of high-energy rays to kill cancer cells and shrink tumors. Radiation therapy affects the cancer cells only in the treated area. The radiation may come from a machine (external radiation) or from putting materials that produce radiation through thin plastic tubes into the area where the cancer cells are found (internal radiation therapy).

* Chemotherapy is the use of anticancer drugs to kill cancer cells throughout the body. Most drugs used to treat mesothelioma are given by injection into a vein (intravenous, or IV). Doctors are also studying the effectiveness of putting chemotherapy directly into the chest or abdomen (intracavitary chemotherapy).

To relieve symptoms and control pain, the doctor may use a needle or a thin tube to drain fluid that has built up in the chest or abdomen. The procedure for removing fluid from the chest is called thoracentesis. Removal of fluid from the abdomen is called paracentesis. Drugs may be given through a tube in the chest to prevent more fluid from accumulating. Radiation therapy and surgery may also be helpful in relieving symptoms.

How is mesothelioma diagnosed?

Diagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions. Diagnosis begins with a review of the patient’s medical history, including any history of asbestos exposure. A complete physical examination may be performed, including x-rays of the chest or abdomen and lung function tests. A CT (or CAT) scan or an MRI may also be useful. A CT scan is a series of detailed pictures of areas inside the body created by a computer linked to an x-ray machine. In an MRI, a powerful magnet linked to a computer is used to make detailed pictures of areas inside the body. These pictures are viewed on a monitor and can also be printed.

A biopsy is needed to confirm a diagnosis of mesothelioma. In a biopsy, a surgeon or a medical oncologist (a doctor who specializes in diagnosing and treating cancer) removes a sample of tissue for examination under a microscope by a pathologist. A biopsy may be done in different ways, depending on where the abnormal area is located. If the cancer is in the chest, the doctor may perform a thoracoscopy. In this procedure, the doctor makes a small cut through the chest wall and puts a thin, lighted tube called a thoracoscope into the chest between two ribs. Thoracoscopy allows the doctor to look inside the chest and obtain tissue samples. If the cancer is in the abdomen, the doctor may perform a peritoneoscopy. To obtain tissue for examination, the doctor makes a small opening in the abdomen and inserts a special instrument called a peritoneoscope into the abdominal cavity. If these procedures do not yield enough tissue, more extensive diagnostic surgery may be necessary.

If the diagnosis is mesothelioma, the doctor will want to learn the stage (or extent) of the disease. Staging involves more tests in a careful attempt to find out whether the cancer has spread and, if so, to which parts of the body. Knowing the stage of the disease helps the doctor plan treatment.

Mesothelioma is described as localized if the cancer is found only on the membrane surface where it originated. It is classified as advanced if it has spread beyond the original membrane surface to other parts of the body, such as the lymph nodes, lungs, chest wall, or abdominal organs.

Incidence of mesothelioma?

Although reported incidence rates have increased in the past 20 years, mesothelioma is still a relatively rare cancer. The incidence is approximately one per 1,000,000. For comparison, populations with high levels of smoking can have a lung cancer incidence of over 1,000 per 1,000,000. Incidence of malignant mesothelioma currently ranges from about 7 to 40 per 1,000,000 in industrialized Western nations, depending on the amount of asbestos exposure of the populations during the past several decades. It has been estimated that incidence may have peaked at 15 per 1,000,000 in the United States in 2004. Incidence is expected to continue increasing in other parts of the world. Mesothelioma occurs more often in men than in women and risk increases with age, but this disease can appear in either men or women at any age. Approximately one fifth to one third of all mesotheliomas are peritoneal.

Between 1940 and 1979, approximately 27.5 million people were occupationally exposed to asbestos in the United States. Between 1973 and 1984, there has been a threefold increase in the diagnosis of pleural mesothelioma in Caucasian males. From 1980 to the late 1990s, the death rate from mesothelioma in the USA increased from 2,000 per year to 3,000, with men four times more likely to acquire it than women. These rates may not be accurate, since it is possible that many cases of mesothelioma are misdiagnosed as adenocarcinoma of the lung, which is difficult to differentiate from mesothelioma.

What are the risk factors for mesothelioma?

Working with asbestos is the major risk factor for mesothelioma. A history of asbestos exposure at work is reported in about 70 percent to 80 percent of all cases. However, mesothelioma has been reported in some individuals without any known exposure to asbestos.

Asbestos is the name of a group of minerals that occur naturally as masses of strong, flexible fibers that can be separated into thin threads and woven. Asbestos has been widely used in many industrial products, including cement, brake linings, roof shingles, flooring products, textiles, and insulation. If tiny asbestos particles float in the air, especially during the manufacturing process, they may be inhaled or swallowed, and can cause serious health problems. In addition to mesothelioma, exposure to asbestos increases the risk of lung cancer, asbestosis (a noncancerous, chronic lung ailment), and other cancers, such as those of the larynx and kidney.

Smoking does not appear to increase the risk of mesothelioma. However, the combination of smoking and asbestos exposure significantly increases a person’s risk of developing cancer of the air passageways in the lung.

What is the mesothelium?

The mesothelium is a membrane that covers and protects most of the internal organs of the body. It is composed of two layers of cells: One layer immediately surrounds the organ; the other forms a sac around it. The mesothelium produces a lubricating fluid that is released between these layers, allowing moving organs (such as the beating heart and the expanding and contracting lungs) to glide easily against adjacent structures.

The mesothelium has different names, depending on its location in the body. The peritoneum is the mesothelial tissue that covers most of the organs in the abdominal cavity. The pleura is the membrane that surrounds the lungs and lines the wall of the chest cavity. The pericardium covers and protects the heart. The mesothelial tissue surrounding the male internal reproductive organs is called the tunica vaginalis testis. The tunica serosa uteri covers the internal reproductive organs in women.

Signs and symptoms of mesothelioma

Symptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space are often symptoms of pleural mesothelioma.

Symptoms of peritoneal mesothelioma include weight loss and cachexia, abdominal swelling and pain due to ascites (a buildup of fluid in the abdominal cavity). Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face.

These symptoms may be caused by mesothelioma or by other, less serious conditions.

Mesothelioma that affects the pleura can cause these signs and symptoms:

* chest wall pain
* pleural effusion, or fluid surrounding the lung
* shortness of breath
* fatigue or anemia
* wheezing, hoarseness, or cough
* blood in the sputum (fluid) coughed up

In severe cases, the person may have many tumor masses. The individual may develop a pneumothorax, or collapse of the lung. The disease may metastasize, or spread, to other parts of the body.

Tumors that affect the abdominal cavity often do not cause symptoms until they are at a late stage. Symptoms include:

* abdominal pain
* ascites, or an abnormal buildup of fluid in the abdomen
* a mass in the abdomen
* problems with bowel function
* weight loss

In severe cases of the disease, the following signs and symptoms may be present:

* blood clots in the veins, which may cause thrombophlebitis
* disseminated intravascular coagulation, a disorder causing severe bleeding in many body organs
* jaundice, or yellowing of the eyes and skin
* low blood sugar level
* pleural effusion
* pulmonary emboli, or blood clots in the arteries of the lungs
* severe ascites

A mesothelioma does not usually spread to the bone, brain, or adrenal glands. Pleural tumors are usually found only on one side of the lungs.

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Via wikipedia.org

What is mesothelioma ?

Mesothelioma is a form of cancer that is almost always caused by previous exposure to asbestos. In this disease, malignant cells develop in the mesothelium, a protective lining that covers most of the body's internal organs. Its most common site is the pleura (outer lining of the lungs and chest cavity), but it may also occur in the peritoneum (the lining of the abdominal cavity) or the pericardium (a sac that surrounds the heart).

Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or have been exposed to asbestos dust and fibre in other ways, such as by washing the clothes of a family member who worked with asbestos, or by home renovation using asbestos cement products. Unlike lung cancer, there is no association between mesothelioma and smoking.

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Definition taken from wikipedia.org